Paulo Dybala found the top corner from Cristiano Ronaldo’s pass to put the hosts ahead at the Allianz Stadium.
Leonardo Bonucci forced home following a goalmouth scramble, before Ronaldo scored his 21st goal of the season in all competitions.
Federico Bernardeschi was thwarted by Frosinone goalkeeper Marco Sportiello in stoppage time.
Second-placed Napoli face Torino at home on Sunday.
Massimiliano Allegri’s Juventus side travel to Atletico Madrid on Wednesday in the first leg of their Champions League last-16 tie.
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